Biology Faculty Articles
Title
Carcinoembryonic Antigen Promotes Colorectal Cancer Progression by Targeting Adherens Junction Complexes
Document Type
Article
Publication Date
6-10-2014
Publication Title
Experimental Cell Research
Keywords
Colorectal carcinoma, Carcinoembryonic antigen, Metastasis, CEAR, RNA binding protein, Adherens junction, E-cadherin, α-catenin, β-catenin, p120 catenin
ISSN
0014-4827
Volume
324
Issue/No.
2
First Page
115
Last Page
123
Abstract
Oncomarkers play important roles in the detection and management of human malignancies. Carcinoembryonic antigen (CEA, CEACAM5) and epithelial cadherin (E-cadherin) are considered as independent tumor markers in monitoring metastatic colorectal cancer. They are both expressed by cancer cells and can be detected in the blood serum. We investigated the effect of CEA production by MIP101 colorectal carcinoma cell lines on E-cadherin adherens junction (AJ) protein complexes. No direct interaction between E-cadherin and CEA was detected; however, the functional relationships between E-cadherin and its AJ partners: α-, β- and p120 catenins were impaired. We discovered a novel interaction between CEA and beta-catenin protein in the CEA producing cells. It is shown in the current study that CEA overexpression alters the splicing of p120 catenin and triggers the release of soluble E-cadherin. The influence of CEA production by colorectal cancer cells on the function of E-cadherin junction complexes may explain the link between the elevated levels of CEA and the increase in soluble E-cadherin during the progression of colorectal cancer.
Additional Comments
Russian Foundation for Fundamental Research grant #: 11-04-01711; Government of the Russian Federation grant #: 11G34.31.0068
NSUWorks Citation
Bajenova, Olga; Nina Chaika; Elena Tolkunova; Alexander Davydov-Sinitsyn; Svetlana Gapon; Peter Thomas; and Stephen J. O'Brien. 2014. "Carcinoembryonic Antigen Promotes Colorectal Cancer Progression by Targeting Adherens Junction Complexes." Experimental Cell Research 324, (2): 115-123. https://nsuworks.nova.edu/cnso_bio_facarticles/424
ORCID ID
0000-0001-7353-8301
ResearcherID
N-1726-2015
Comments
©2014 Elsevier Inc. All rights reserved.