ERV3, a Full-Length Human Endogenous Provirus: Chromosomal Localization and Evolutionary Relationships

Authors

• Cathy O'Connell, National Cancer Institute at Frederick
• Stephen J. O'Brien, National Cancer Institute at FrederickFollow
• William G. Nash, National Cancer Institute at Frederick
• Maurice Cohen, National Cancer Institute at Frederick

ORCID

0000-0001-7353-8301

ResearcherID

N-1726-2015

Document Type

Article

Publication Title

Virology

ISSN

0042-6822

Publication Date

10-30-1984

Abstract

A full-length human endogenous provirus termed ERV3 was isolated from a human fetal recombinant DNA library by low stringency hybridization with two probes: baboon endogenous virus LTR; and a pol-env subclone from the endogenous chimpanzee provirus, CH2. DNA sequencing within the clone and comparisons with other retroviruses revealed that ERV3 contains gag and pol gene sequences that are significantly related to those of mammalian type C retroviruses and previously described human endogenous proviruses. The ERV3 genome was determined to reside at a single locus on human chromosome 7 using a panel of rodent X human somatic cell hybrids.

Volume

138

Issue

2

First Page

225

Last Page

235

Comments

© 1984 Published by Elsevier Inc.

NSUWorks Citation

O'Connell, Cathy; Stephen J. O'Brien; William G. Nash; and Maurice Cohen. 1984. "ERV3, a Full-Length Human Endogenous Provirus: Chromosomal Localization and Evolutionary Relationships." Virology 138, (2): 225-235. https://nsuworks.nova.edu/cnso_bio_facarticles/390