Biology Faculty Articles
Title
Chromosomal Localization of the met Proto-Oncogene in the Mouse and Cat Genome
Document Type
Article
Publication Date
10-1987
Publication Title
Genomics
ISSN
0888-7543
Volume
1
Issue/No.
2
First Page
167
Last Page
173
Abstract
The met proto-oncogene was mapped in the mouse and cat genomes with the use of mouse × hamster and cat × rodent somatic cell hybrid DNA panels. Based on these analyses we assigned the met gene to mouse chromosome 6 and to cat chromosome A2. We also assigned the cat raf-1 proto-oncogene to the A2 chromosome; met and raf-1 are the first cloned DNAs mapped to this linkage group. Using an interspecies backcross we further localized met on mouse chromosome 6 to a position proximal to the β chain of the T-cell receptor. This places met near the obese locus in a region of mouse chromosome 6 that appears to be homologous with the long arm of human chromosome 7. The close linkage of met to the gene responsible for cystic fibrosis in humans suggests that further genetic analysis of mouse chromosome 6 may be useful in developing a mouse model for the disease.
Additional Comments
National Cancer Institute contract #: N01-CO-23909
NSUWorks Citation
Dean, Michael; Christine Kozak; Joan Robbins; Robert Callahan; Stephen J. O'Brien; and George F. Vande Woude. 1987. "Chromosomal Localization of the met Proto-Oncogene in the Mouse and Cat Genome." Genomics 1, (2): 167-173. https://nsuworks.nova.edu/cnso_bio_facarticles/361
ORCID ID
0000-0001-7353-8301
ResearcherID
N-1726-2015
Comments
© 1987 Published by Elsevier Inc.