Biology Faculty Articles

Title

Chromosomal Localization of the met Proto-Oncogene in the Mouse and Cat Genome

Document Type

Article

Publication Date

10-1987

Publication Title

Genomics

ISSN

0888-7543

Volume

1

Issue/No.

2

First Page

167

Last Page

173

Abstract

The met proto-oncogene was mapped in the mouse and cat genomes with the use of mouse × hamster and cat × rodent somatic cell hybrid DNA panels. Based on these analyses we assigned the met gene to mouse chromosome 6 and to cat chromosome A2. We also assigned the cat raf-1 proto-oncogene to the A2 chromosome; met and raf-1 are the first cloned DNAs mapped to this linkage group. Using an interspecies backcross we further localized met on mouse chromosome 6 to a position proximal to the β chain of the T-cell receptor. This places met near the obese locus in a region of mouse chromosome 6 that appears to be homologous with the long arm of human chromosome 7. The close linkage of met to the gene responsible for cystic fibrosis in humans suggests that further genetic analysis of mouse chromosome 6 may be useful in developing a mouse model for the disease.

Comments

© 1987 Published by Elsevier Inc.

Additional Comments

National Cancer Institute contract #: N01-CO-23909

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015

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Peer Reviewed

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