The Lake Casitas Wild Mouse: Evolving Genetic Resistance to Retroviral Disease

Authors

• Murray B. Gardner, University of California - Davis
• Christine Kozak, National Institute of Allergy and Infectious Diseases
• Stephen J. O'Brien, National Cancer Institute at FrederickFollow

ORCID

0000-0001-7353-8301

ResearcherID

N-1726-2015

Document Type

Article

Publication Title

Trends in Genetics

ISSN

0168-9525

Publication Date

1-1991

Abstract

A small colony of feral mice from California continues to flourish in spite of virulent epizootic of pathological retrovirus. Epidemiological and genetic studies revealed that the viral infection is strongly balanced by the polymorphic resistance locus, Fv-4, a transcriptionally active but truncated provirus that originated in the East Asian ancestors of the Californian mice. The natural history of these populations represents a graphic example of genomic adaptation in free-ranging populations to regulate and delimit infectious disease.

Volume

7

Issue

1

First Page

22

Last Page

27

Comments

© 1991 Published by Elsevier Ltd.

NSUWorks Citation

Gardner, Murray B.; Christine Kozak; and Stephen J. O'Brien. 1991. "The Lake Casitas Wild Mouse: Evolving Genetic Resistance to Retroviral Disease." Trends in Genetics 7, (1): 22-27. https://nsuworks.nova.edu/cnso_bio_facarticles/343