Title

The Lake Casitas Wild Mouse: Evolving Genetic Resistance to Retroviral Disease

Authors

Murray B. Gardner, University of California - Davis
Christine Kozak, National Institute of Allergy and Infectious Diseases
Stephen J. O'Brien, National Cancer Institute at FrederickFollow

Document Type

Article

Publication Date

1-1991

Publication Title

Trends in Genetics

ISSN

0168-9525

Volume

7

Issue/No.

1

First Page

22

Last Page

27

Abstract

A small colony of feral mice from California continues to flourish in spite of virulent epizootic of pathological retrovirus. Epidemiological and genetic studies revealed that the viral infection is strongly balanced by the polymorphic resistance locus, Fv-4, a transcriptionally active but truncated provirus that originated in the East Asian ancestors of the Californian mice. The natural history of these populations represents a graphic example of genomic adaptation in free-ranging populations to regulate and delimit infectious disease.

Comments

© 1991 Published by Elsevier Ltd.

NSUWorks Citation

Gardner, Murray B.; Christine Kozak; and Stephen J. O'Brien. 1991. "The Lake Casitas Wild Mouse: Evolving Genetic Resistance to Retroviral Disease." Trends in Genetics 7, (1): 22-27. https://nsuworks.nova.edu/cnso_bio_facarticles/343

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015