Title

Monocyte-Derived Neutrophil Chemotactic Factor (MDNCF/IL-8) Resides in a Gene Cluster along with Several Other Members of the Platelet Factor 4 Gene Superfamily

Authors

William Modi, National Cancer Institute at Frederick
Michael Dean, National Cancer Institute at Frederick
Hector Seuanez, National Cancer Institute at Frederick
Naofumi Mukaida, National Cancer Institute at Frederick
Kouji Matsushima, National Cancer Institute at Frederick
Stephen J. O'Brien, National Cancer Institute at FrederickFollow

Document Type

Article

Publication Date

1-1990

Publication Title

Human Genetics

ISSN

0340-6717

Volume

84

Issue/No.

2

First Page

185

Last Page

187

Abstract

Monocyte-derived neutrophil chemotactic factor (MDNCF/IL-8, suggested gene symbol IL8) is a cytokine that chemoattracts and activates neutrophils. Using a panel of human-rodent cell hybrids that preferentially segregate human chromosomes and in situ hybridization, the MDNCF/IL-8 gene was placed on the human gene map at position 4q12-q21. This is the same location where at least three other members (platelet factor 4, melanoma growth stimulatory activity, and interferon-γ induced factor) of the platelet factor 4 gene superfamily reside. In addition, a restriction fragment length polymorphism was identified using MDNCF as a probe in screening genomic DNA digested with HindIII from unrelated individuals.

Comments

©1990 Springer-Verlag

NSUWorks Citation

Modi, William; Michael Dean; Hector Seuanez; Naofumi Mukaida; Kouji Matsushima; and Stephen J. O'Brien. 1990. "Monocyte-Derived Neutrophil Chemotactic Factor (MDNCF/IL-8) Resides in a Gene Cluster along with Several Other Members of the Platelet Factor 4 Gene Superfamily." Human Genetics 84, (2): 185-187. https://nsuworks.nova.edu/cnso_bio_facarticles/339

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015