Linkage Mapping of Human Polymorphic Proteins Identified by Two-Dimensional Electrophoresis

Authors

• David Goldman, National Institute on Alcohol Abuse and Alcoholism
• Stephen J. O'Brien, National Cancer Institute at FrederickFollow
• Susan Lucas-Derse, National Cancer Institute at Frederick
• Michael Dean, National Cancer Institute at Frederick

ORCID

0000-0001-7353-8301

ResearcherID

N-1726-2015

Document Type

Article

Publication Title

Genomics

ISSN

0888-7543

Publication Date

12-1991

Abstract

Nineteen polymorphic lymphocyte proteins were previously detected by two-dimensional protein electrophoresis (2DE). In this report, we describe the genetic linkage mapping of six of these polymorphic proteins (PNIA1–PNIA6), the identification by genetic linkage of a seventh (glyoxalase 1 on 6p21), and support for the mapping of an eighth (plastin or LCP1) to near the ESD locus on Chr 13. PNIA1–PNIA6 were assigned, respectively, to 10q26, 16p13.3, 10q, 11p15, 3q, and 19q13. These genetic linkages were achieved by classical linkage analysis of 2DE protein charge polymorphisms to the panel of RFLPs previously typed in nine pedigrees in the Centre D'Etude du Polymorphisme Humain (CEPH) collection.

Volume

11

Issue

4

First Page

875

Last Page

884

Comments

© 1991 Published by Elsevier Inc.

NSUWorks Citation

Goldman, David; Stephen J. O'Brien; Susan Lucas-Derse; and Michael Dean. 1991. "Linkage Mapping of Human Polymorphic Proteins Identified by Two-Dimensional Electrophoresis." Genomics 11, (4): 875-884. https://nsuworks.nova.edu/cnso_bio_facarticles/333