Title

Linkage Disequilibrium in Admixed Populations: Applications in Gene Mapping

Authors

D. Briscoe, National Cancer Institute at Frederick
J. Claiborne Stephens, National Cancer Institute at Frederick
Stephen J. O'Brien, National Cancer Institute at FrederickFollow

Document Type

Article

Publication Date

1-1994

Publication Title

Journal of Heredity

ISSN

0022-1503

Volume

85

Issue/No.

1

First Page

59

Last Page

63

Abstract

A method to detect linkage of genetic traits to polymorphic DNA markers in outbred populations when pedigree analysis is not feasible is presented. The procedure takes advantage of increased linkage disequilibrium that occurs when isolated races or subspecies mate and interbreed. By selecting restriction fragment length polymorphism (RFLP) or microsatellite marker loci that have different allele frequencies in admixed populations, genetic associations produced de novo by hybridization will persist as a function of θ (map distance) for 10–20 generations after initial interbreeding. By careful selection of loci and study populations, the procedure detects linkage of traits otherwise refractory to linkage analysis.

Comments

©1994 The American Genetic Association

NSUWorks Citation

Briscoe, D.; J. Claiborne Stephens; and Stephen J. O'Brien. 1994. "Linkage Disequilibrium in Admixed Populations: Applications in Gene Mapping." Journal of Heredity 85, (1): 59-63. https://nsuworks.nova.edu/cnso_bio_facarticles/277

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015