Biology Faculty Articles
Title
Polymorphic Admixture Typing in Human Ethnic Populations
Document Type
Article
Publication Date
10-1994
Publication Title
American Journal of Human Genetics
ISSN
0002-9297
Volume
55
Issue/No.
4
First Page
788
Last Page
808
Abstract
A panel of 257 RFLP loci was selected on the basis of high heterozygosity in Caucasian DNA surveys and equivalent spacing throughout the human genome. Probes from each locus were used in a Southern blot survey of allele frequency distribution for four human ethnic groups: Caucasian, African American, Asian (Chinese), and American Indian (Cheyenne). Nearly all RFLP loci were polymorphic in each group, albeit with a broad range of differing allele frequencies (δ). The distribution of frequency differences (δ values) was used for three purposes: (1) to provide estimates for genetic distance (differentiation) among these ethnic groups, (2) to revisit with a large data set the proportion of human genetic variation attributable to differentiation within ethnic groups, and (3) to identify loci with high δ values between recently admixed populations of use in mapping by admixture linkage disequilibrium (MALD). Although most markers display significant allele frequency differences between ethnic groups, the overall genetic distances between ethnic groups were small (.066–.098), and
Additional Comments
PMC1918306
NSUWorks Citation
Dean, Michael; J. Claiborne Stephens; Cheryl Winkler; Deborah A. Lomb; Mark Ramsburg; Raleigh Boaze; Claudia Stewart; Lauren Charbonneau; David Goldman; Bernard J. Albaugh; James J. Goedert; R. Palmer Beasley; Lu-Yu Hwang; Susan Buchbinder; Michael Weedon; Patricia A. Johnson; Mary Eichelberger; and Stephen J. O'Brien. 1994. "Polymorphic Admixture Typing in Human Ethnic Populations." American Journal of Human Genetics 55, (4): 788-808. https://nsuworks.nova.edu/cnso_bio_facarticles/258
ORCID ID
0000-0001-7353-8301
ResearcherID
N-1726-2015
Comments
©1994 by The American Society of Human Genetics