Title

Akvr-1, a Dominant Murine Leukemia Virus Restriction Gene, is Polymorphic in Leukemia-Prone Wild Mice

Authors

Murray B. Gardner, University of Southern California
Suraiya Rasheed, University of Southern California
BIjay K. Pal, University of Southern California
John D. Estes, University of Southern California
Stephen J. O'Brien, National Cancer Institute, BethesdaFollow

Document Type

Article

Publication Date

1-15-1980

Publication Title

Proceedings of the National Academy of Sciences of the United States of America

Keywords

Murine leukemia virus regulation, Retrovirus control gene

ISSN

1091-6490

Volume

77

Issue/No.

1

First Page

531

Last Page

535

Abstract

We describe a restriction gene (Akvr-1, for AKR virus restriction) that is polymorphic for two alleles, Akvr-1^R (restrictive) and Akvr-1^r (susceptible), in a feral population of mice (Mus musculus domesticus) at a squab farm near Lake Casitas (LC) in southern California. Akvr-1^R is a dominant allele that exhibits 100% penetrance in prevention of viremia of AKR endogenous retrovirus and of virus-mediated lymphoma in LC (Akvr-1^RR) X AKR F₁ hybrids. The restriction phenotype segregates as a single Mendelian locus in backcrosses to AKR mice. Akvr-1^R likewise is effective in restriction of NB-tropic Moloney murine leukemia virus-induced viremia and NB-tropic Friend virus-induced splenomegaly but fails to restrict expression or pathogenesis of LC-derived amphotropic retrovirus. Pleiotropic restriction of AKR, Friend, and Moloney ecotropic viruses, but not of amphotropic virus, suggests that the viral targets of Akvr-1 in the three ecotropic viruses are similar to each other and distinct from the target in the LC-amphotropic virus. The relationship of Akvr-1 to previously reported murine restriction loci Fv-1, Fv-2, and Fv-4 is discussed.

Additional Comments

Contract #N01-CP8-1032

NSUWorks Citation

Gardner, Murray B.; Suraiya Rasheed; BIjay K. Pal; John D. Estes; and Stephen J. O'Brien. 1980. "Akvr-1, a Dominant Murine Leukemia Virus Restriction Gene, is Polymorphic in Leukemia-Prone Wild Mice." Proceedings of the National Academy of Sciences of the United States of America 77, (1): 531-535. doi:10.1073/pnas.77.1.531.

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015

DOI

10.1073/pnas.77.1.531