Biology Faculty Articles
Conserved Regions of Homologous G-Banded Chromosomes Between Orders in Mammalian Evolution: Carnivores and Primates
ORCID
0000-0001-7353-8301
ResearcherID
N-1726-2015
Document Type
Article
Publication Title
Proceedings of the National Academy of Sciences of the United States of America
ISSN
1091-6490
Publication Date
11-1-1982
Keywords
Comparative gene mapping, Cytogenetics, Felidae, Isozyme
Abstract
The recent derivation of a biochemical map of 33 loci of the domestic cat (Felis catus) revealed a striking conservation of chromosomal linkage associations between the cat and humans. A comparison of homologous (by linkage criteria) chromosomes by using conventionally extended and high-resolution G-banding of human and feline chromosomes is presented. Four criteria for establishing probable cytogenetic homologies of chromosomal regions were invoked: (i) map placement of homologous genes to the same chromosomes; (ii) cytological correlation of G-banding pattern; (iii) placement of homologous genes, by regional gene mapping, in the region of cytological homology; and (iv) a requirement that the putative region of homology be ancestral and evolutionarily conserved within their respective orders. Five subchromosomal regions (homologous to human chromosome 1p, 2p, 2q, 12, and X) were found to be conserved and homologous by all the stated criteria. The conserved regions constitute nearly 20% by length of the human chromosomal genome. The implications of conservation of chromosome homologies between mammalian orders whose last common ancestor became extinct more than 60 million years ago is discussed.
DOI
10.1073/pnas.79.21.6631
Volume
79
Issue
21
First Page
6631
Last Page
6635
NSUWorks Citation
Nash, William G. and Stephen J. O'Brien. 1982. "Conserved Regions of Homologous G-Banded Chromosomes Between Orders in Mammalian Evolution: Carnivores and Primates." Proceedings of the National Academy of Sciences of the United States of America 79, (21): 6631-6635. doi:10.1073/pnas.79.21.6631.
