Biology Faculty Articles

Title

Conserved Regions of Homologous G-Banded Chromosomes Between Orders in Mammalian Evolution: Carnivores and Primates

Document Type

Article

Publication Date

11-1-1982

Publication Title

Proceedings of the National Academy of Sciences of the United States of America

Keywords

Comparative gene mapping, Cytogenetics, Felidae, Isozyme

ISSN

1091-6490

Volume

79

Issue/No.

21

First Page

6631

Last Page

6635

Abstract

The recent derivation of a biochemical map of 33 loci of the domestic cat (Felis catus) revealed a striking conservation of chromosomal linkage associations between the cat and humans. A comparison of homologous (by linkage criteria) chromosomes by using conventionally extended and high-resolution G-banding of human and feline chromosomes is presented. Four criteria for establishing probable cytogenetic homologies of chromosomal regions were invoked: (i) map placement of homologous genes to the same chromosomes; (ii) cytological correlation of G-banding pattern; (iii) placement of homologous genes, by regional gene mapping, in the region of cytological homology; and (iv) a requirement that the putative region of homology be ancestral and evolutionarily conserved within their respective orders. Five subchromosomal regions (homologous to human chromosome 1p, 2p, 2q, 12, and X) were found to be conserved and homologous by all the stated criteria. The conserved regions constitute nearly 20% by length of the human chromosomal genome. The implications of conservation of chromosome homologies between mammalian orders whose last common ancestor became extinct more than 60 million years ago is discussed.

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015

DOI

10.1073/pnas.79.21.6631

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