Biology Faculty Articles
Title
Conserved Chromosomal Positions of Dual Domains of the ets Protooncogene in Cats, Mice, and Humans
Document Type
Article
Publication Date
3-15-1986
Publication Title
Proceedings of the National Academy of Sciences of the United States of America
Keywords
Comparative gene mapping, Leukemia
ISSN
1091-6490
Volume
83
Issue/No.
6
First Page
1792
Last Page
1796
Abstract
The mammalian protooncogene homologue of the avian v-ets sequence from the E26 retrovirus consists of two sequentially distinct domains located on different chromosomes. Using somatic cell hybrid panels, we have mapped the mammalian homologue of the 5' v-ets-domain to chromosome 11 (ETS1) in man, to chromosome 9 (Ets-1) in mouse, and to chromosome D1 (ETS1) in the domestic cat. The mammalian homologue of the 3' v-ets domain was similarly mapped to human chromosome 21 (ETS2), to mouse chromosome 16 (Ets-2), and to feline chromosome C2 (ETS2). Both protooncogenes fell in syntenic groups of homologous linked loci that were conserved among the three species. The occurrence of two distinct functional protooncogenes and their conservation of linkage positions in the three mammalian orders indicate that these two genes have been separate since before the evolutionary divergence of mammals.
NSUWorks Citation
Watson, Dennis K.; Mary J. McWilliams-Smith; Christine Kozak; Roger Reeves; John Gearheart; Michael F. Nunn; William Nash; John R. Fowle III; Peter Duesberg; Takis S. Papas; and Stephen J. O'Brien. 1986. "Conserved Chromosomal Positions of Dual Domains of the ets Protooncogene in Cats, Mice, and Humans." Proceedings of the National Academy of Sciences of the United States of America 83, (6): 1792-1796. https://nsuworks.nova.edu/cnso_bio_facarticles/244
ORCID ID
0000-0001-7353-8301
ResearcherID
N-1726-2015
