Title

Novel Gene Conversion Between X-Y Homologues Located in the Nonrecombining Region of the Y Chromosome in Felidae (Mammalia)

Authors

Jill Pecon Slattery, National Cancer Institute at Frederick
Leslie Sanner-Wachter, National Cancer Institute at Frederick
Stephen J. O'Brien, National Cancer Institute at FrederickFollow

Document Type

Article

Publication Date

5-9-2000

Publication Title

Proceedings of the National Academy of Sciences of the United States of America

ISSN

1091-6490

Volume

97

Issue/No.

10

First Page

5307

Last Page

5312

Abstract

Genes located on the mammalian Y chromosome outside of the pseudoautosomal region do not recombine with those on the X and are predicted to either undergo selection for male function or gradually degenerate because of an accumulation of deleterious mutations. Here, phylogenetic analyses of X-Y homologues, Zfx and Zfy, among 26 felid species indicate two ancestral episodes of directed genetic exchange (ectopic gene conversion) from X to Y: once during the evolution of pallas cat and once in a common predecessor of ocelot lineage species. Replacement of the more rapidly evolving Y homologue with the evolutionarily constrained X copy may represent a mechanism for adaptive editing of functional genes on the nonrecombining region of the mammalian Y chromosome.

Additional Comments

GenBank Accession #s: AF252969-AF253020

NSUWorks Citation

Slattery, Jill Pecon; Leslie Sanner-Wachter; and Stephen J. O'Brien. 2000. "Novel Gene Conversion Between X-Y Homologues Located in the Nonrecombining Region of the Y Chromosome in Felidae (Mammalia)." Proceedings of the National Academy of Sciences of the United States of America 97, (10): 5307-5312. https://nsuworks.nova.edu/cnso_bio_facarticles/228

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015