Title

Amplification and Chromosomal Dispersion of Human Endogenous Retroviral Sequences

Authors

Paul E. Steele, National Institute of Allergy and Infectious Diseases
Malcolm A. Martin, National Institute of Allergy and Infectious Diseases
Arnold B. Rabson, National Institute of Allergy and Infectious Diseases
Theodore Bryan, National Institute of Allergy and Infectious Diseases
Stephen J. O'Brien, National Cancer Institute at FrederickFollow

Document Type

Article

Publication Date

9-1986

Publication Title

Journal of Virology

ISSN

0022-538X

Volume

59

Issue/No.

3

First Page

545

Last Page

550

Abstract

Endogenous retroviral sequences in humans have undergone amplification events involving both viral and flanking cellular sequences. We cloned members of an amplified family of full-length endogenous retroviral sequences. Genomic blotting, employing a flanking cellular DNA probe derived from a member of this family, revealed a similar array of reactive bands in both humans and chimpanzees, indicating that an amplification event involving retroviral and associated cellular DNA sequences occurred before the evolutionary separation of these two primates. Southern analyses of restricted somatic cell hybrid DNA preparations suggested that endogenous retroviral segments are widely dispersed in the human genome and that amplification and dispersion events may be linked.

Comments

©1986, American Society for Microbiology

NSUWorks Citation

Steele, Paul E.; Malcolm A. Martin; Arnold B. Rabson; Theodore Bryan; and Stephen J. O'Brien. 1986. "Amplification and Chromosomal Dispersion of Human Endogenous Retroviral Sequences." Journal of Virology 59, (3): 545-550. https://nsuworks.nova.edu/cnso_bio_facarticles/220

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015