Biology Faculty Articles
Document Type
Article
Publication Date
4-2005
Publication Title
Journal of Virology
ISSN
0022-538X
Volume
79
Issue/No.
7
First Page
3979
Last Page
3986
Abstract
The number, chromosomal distribution, and insertional polymorphisms of endogenous feline leukemia viruses (enFeLVs) were determined in four domestic cats (Burmese, Egyptian Mau, Persian, and nonbreed) using fluorescent in situ hybridization and radiation hybrid mapping. Twenty-nine distinct enFeLV loci were detected across 12 of the 18 autosomes. Each cat carried enFeLV at only 9 to 16 of the loci, and many loci were heterozygous for presence of the provirus. Thus, an average of 19 autosomal copies of enFeLV were present per cat diploid genome. Only five of the autosomal enFeLV sites were present in all four cats, and at only one autosomal locus, B4q15, was enFeLV present in both homologues of all four cats. A single enFeLV occurred in the X chromosome of the Burmese cat, while three to five enFeLV proviruses occurred in each Y chromosome. The X chromosome and nine autosomal enFeLV loci were telomeric, suggesting that ectopic recombination between nonhomologous subtelomeres may contribute to enFeLV distribution. Since endogenous FeLVs may affect the infectiousness or pathogenicity of exogenous FeLVs, genomic variation in enFeLVs represents a candidate for genetic influences on FeLV leukemogenesis in cats.
Additional Comments
NIH contract #: N01-CO-12400; GenBank accession #s: AY364320-AY364322
NSUWorks Citation
Roca, Alfred L.; William G. Nash; Joan C. Menninger; William J. Murphy; and Stephen J. O'Brien. 2005. "Insertional Polymorphisms of Endogenous Feline Leukemia Viruses." Journal of Virology 79, (7): 3979-3986. https://nsuworks.nova.edu/cnso_bio_facarticles/206
ORCID ID
0000-0001-7353-8301
ResearcherID
N-1726-2015
Included in
Animal Sciences Commons, Genetics and Genomics Commons, Veterinary Medicine Commons, Virology Commons
Comments
© 2005, American Society for Microbiology