Title

Association of DC-SIGN Promoter Polymorphism with Increased Risk for Parenteral, but Not Mucosal, Acquisition of Human Immunodeficiency Virus Type 1 Infection

Authors

Maureen P. Martin, National Cancer Institute at Frederick
Michael M. Lederman, Case Western Reserve University
Holli B. Hutcheson, National Cancer Institute at Frederick
James J. Goedert, National Cancer Institute at Bethesda
George W. Nelson, National Cancer Institute at Frederick
Yvette van Kooyk, Vrije Universiteit Medical Center - Amsterdam
Roger Detels, University of California, Los Angeles
Susan Buchbinder, San Francisco Department of Public Health
Keith Hoots, University of Texas Health Science Center at Houston
David Vlahov, New York Academy of Medicine
Stephen J. O'Brien, National Cancer Institute at FrederickFollow
Mary Carrington, National Cancer Institute at Frederick

Document Type

Article

Publication Date

12-2004

Publication Title

Journal of Virology

ISSN

0022-538X

Volume

78

Issue/No.

24

First Page

14053

Last Page

14056

Abstract

There is considerable debate about the fundamental mechanisms that underlie and restrict acquisition of human immunodeficiency virus type 1 (HIV-1) infection. In light of recent studies demonstrating the ability of C type lectins to facilitate infection with HIV-1, we explored the potential relationship between polymorphisms in the DC-SIGN promoter and risk for acquisition of HIV-1 according to route of infection. Using samples obtained from 1,611 European-American participants at risk for parenteral (n = 713) or mucosal (n = 898) infection, we identified single-nucleotide polymorphisms in the DC-SIGN promoter using single-strand conformation polymorphism. Individuals at risk for parenterally acquired infection who had −336C were more susceptible to infection than were persons with −336T (odds ratio = 1.87, P = 0.001). This association was not observed in those at risk for mucosally acquired infection. A potential role for DC-SIGN specific to systemic acquisition and dissemination of infection is suggested.

Comments

© 2004, American Society for Microbiology

Additional Comments

NIH contract #: NO1-CO-12400

NSUWorks Citation

Martin, Maureen P.; Michael M. Lederman; Holli B. Hutcheson; James J. Goedert; George W. Nelson; Yvette van Kooyk; Roger Detels; Susan Buchbinder; Keith Hoots; David Vlahov; Stephen J. O'Brien; and Mary Carrington. 2004. "Association of DC-SIGN Promoter Polymorphism with Increased Risk for Parenteral, but Not Mucosal, Acquisition of Human Immunodeficiency Virus Type 1 Infection." Journal of Virology 78, (24): 14053-14056. https://nsuworks.nova.edu/cnso_bio_facarticles/205

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015