Title

Mannose Binding Lectin Genotypes Influence Recovery from Hepatitis B Virus Infection

Authors

Chloe L. Thio, Johns Hopkins University
Timothy L. Mosbruger, Johns Hopkins University
Jacquie Astemborski, Johns Hopkins University
Spencer Greer, Johns Hopkins University
Gregory D. Kirk, Johns Hopkins University
Stephen J. O'Brien, National Cancer Institute at FrederickFollow
David L. Thomas, Johns Hopkins University

Document Type

Article

Publication Date

7-2005

Publication Title

Journal of Virology

ISSN

0022-538X

Volume

79

Issue/No.

14

First Page

9192

Last Page

9196

Abstract

Mannose binding lectin (MBL) is a central component of the innate immune response and thus may be important for determining hepatitis B virus (HBV) persistence. Since single-nucleotide polymorphisms (SNPs) in the gene encoding MBL (mbl2) alter the level of functional MBL, we hypothesized that mbl2 genotypes are a determinant of HBV persistence or recovery from viral infection. We tested this hypothesis by using a nested case control design with 189 persons with HBV persistence matched to 338 individuals who had naturally recovered from HBV infection. We determined genotypes of two promoter and three exon 1 SNPs in mbl2 and grouped these genotypes according to the amount of functional MBL production. We found that the promoter SNP −221C, which leads to deficient MBL production, was more common in those subjects with viral persistence (odds ratio [OR], 1.38; 95% confidence interval [CI], 1.01 to 1.89; P = 0.04). Those subjects homozygous for the combination of promoter and exon 1 genotypes associated with the highest amount of functional MBL had significantly increased odds of recovery from infection (OR, 0.55; 95% CI, 0.37 to 0.84; P = 0.005). Conversely, those homozygous for the combination of promoter and exon 1 genotypes which produce the lowest amount of functional MBL were more likely to have viral persistence (OR, 1.76; 95% CI, 1.02 to 3.01; P = 0.04). These data are consistent with the hypothesis that functional MBL plays a central role in the pathogenesis of acute hepatitis B.

Comments

© 2005, American Society for Microbiology

Additional Comments

NIH grants: DA00441, DA12568, DA04334, DK56415, NO1-CO-12400; NCI grants: UO1-AI-35042, 5-MO1-RR-00722 (GCRC), UO1-AI-35043, UO1-AI-37984, UO1-AI-35039, UO1-AI-35040, UO1-AI-37613, UO1-AI-35041

NSUWorks Citation

Thio, Chloe L.; Timothy L. Mosbruger; Jacquie Astemborski; Spencer Greer; Gregory D. Kirk; Stephen J. O'Brien; and David L. Thomas. 2005. "Mannose Binding Lectin Genotypes Influence Recovery from Hepatitis B Virus Infection." Journal of Virology 79, (14): 9192-9196. https://nsuworks.nova.edu/cnso_bio_facarticles/204

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015