Genetic Variance of Laboratory Outbred Swiss Mice

Authors

• M. Catherine Rice, National Cancer Institute at Bethesda
• Stephen J. O'Brien, National Cancer Institute at BethesdaFollow

ORCID

0000-0001-7353-8301

ResearcherID

N-1726-2015

Document Type

Article

Publication Title

Nature

ISSN

0028-0836

Publication Date

1-10-1980

Abstract

The extent of allelic variation has been estimated at 46 structural gene loci within three major colonies of Swiss mice and between inbred derivative strains. The colonies have retained nearly the same amount and type of variation found in natural murine or human populations despite laboratory propagation for more than 50 years (175 generations). The population genetic structures of the Swiss mouse colonies were comparable to an island population in which random fixation, and not inbreeding or population bottlenecks, is apparently responsible for slight losses in genetic variance.

DOI

10.1038/283157a0

Volume

283

Issue

5743

First Page

157

Last Page

161

Comments

©1980 Macmillan Journals Ltd

NSUWorks Citation

Rice, M. Catherine and Stephen J. O'Brien. 1980. "Genetic Variance of Laboratory Outbred Swiss Mice." Nature 283, (5743): 157-161. doi:10.1038/283157a0.