Biology Faculty Articles

Title

Isolation of HTLV-Transformed B-Lymphocyte Clone from a Patient with HTLV-Associated Adult T-Cell Leukaemia

Document Type

Article

Publication Date

8-9-1984

Publication Title

Nature

ISSN

0028-0836

Volume

310

Issue/No.

5977

First Page

505

Last Page

506

Abstract

The human T-cell leukaemia/lymphoma virus (HTLV) is an exogenous retrovirus which has been associated with adult T-cell leukaemia/lymphoma (ATL). This malignancy of T lymphocytes is endemic to southern Japan, the West Indies, and to a lesser extent, the Middle East, Central Africa and the southeastern United States. ATL cells from patients of diverse geographical origins have been found to be infected with HTLV-1. HTLV is normally tropic for mature T lymphocytes, especially those expressing the helper-inducer surface antigen phenotype (OKT4 or Leu-3-positive), and the neoplastic T cells infected with HTLV generally express receptors for T-cell growth factor (detected by reactivity with anti-Tac antibody). However, we report here the isolation of a HTLV-infected B-lymphocyte clone from the peripheral blood of a patient with ATL. This clone is cytogenetically normal and is not infected with Epstein-Barr virus (EBV). Co-culture of cells from this clone with cord blood lymphocytes resulted in transmission of HTLV and the immortalization of either T or B lymphocytes. These results suggest that HTLV may be associated with a broader range of host cells than previously recognized.

Comments

©1984 Nature Publishing Group

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015

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