Identification of an Amplified, Highly Expressed Gene in a Human Glioma

Authors

• Kenneth W. Kinzler, Johns Hopkins University School of Medicine
• Sandra H. Bigner, Duke University Medical Center
• Darrell D. Bigner, Duke University Medical Center
• Jeffrey M. Trent, University of Arizona - Tucson
• Martha L. Law, University of Colorado - Denver
• Stephen J. O'Brien, National Cancer Institute at FrederickFollow
• Albert J. Wong, Johns Hopkins University School of Medicine
• Bert Vogelstein, Johns Hopkins University School of Medicine

ORCID

0000-0001-7353-8301

ResearcherID

N-1726-2015

Document Type

Article

Publication Title

Science

ISSN

0036-8075

Publication Date

4-3-1987

Abstract

A gene, termed gli, was identified that is amplified more than 50-fold in a malignant glioma. The gene is expressed at high levels in the original tumor and its derived cell line and is located at chromosome 12 position (q13 to q14.3). The gli gene is a member of a select group of cellular genes that are genetically altered in primary human tumors.

Volume

236

Issue

4797

First Page

70

Last Page

73

Comments

©1987 American Association for the Advancement of Science

NSUWorks Citation

Kinzler, Kenneth W.; Sandra H. Bigner; Darrell D. Bigner; Jeffrey M. Trent; Martha L. Law; Stephen J. O'Brien; Albert J. Wong; and Bert Vogelstein. 1987. "Identification of an Amplified, Highly Expressed Gene in a Human Glioma." Science 236, (4797): 70-73. https://nsuworks.nova.edu/cnso_bio_facarticles/155