Biology Faculty Articles
Title
Preoperative transcatheter arterial chemotherapy may suppress oxidative stress in hepatocellular carcinoma cells and reduce the risk of short-term relapse
Document Type
Article
Publication Date
1-1-2017
Publication Title
Oncotarget
Keywords
Hepatocellular carcinoma, Oxidative stress, P21 waf1/cip1, TP53, Transcatheter arterial chemotherapy
ISSN
19492553
Volume
8
Issue/No.
33
First Page
54402
Last Page
54415
Abstract
In this study, we aim to investigate oxidative stress in hepatocellular carcinoma (HCC) tissues in patients receiving preoperative transcatheter arterial chemotherapy (TAC) and its association with prognosis. A total of 89 HCC patients enrolled in this study, 39 received preoperative TAC 1 week before surgery (pTAC group) and 50 did not (non-pTAC group). All patients underwent hepatectomy and postoperative TAC and were followed up to 400 weeks. Samples of liver tissue without HCC and hepatitis (n = 15) served as normal controls. Cellular levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG), TP53, and p21waf1/cip1 were measured in both cancer and surrounding tissues using an immunohistochemistry assay. Taken together, our data suggested that preoperative TAC might postpone postoperative HCC relapse within 1 year via suppression of tumor cells by induction of high levels of oxidative stress.
NSUWorks Citation
Su, Hao; Guangzhi Zhu; Ketut Indra Djaja P; Yi Lin; Yizhen Gong; Xiaoguang Liu; Jiaquan Li; Zhiming Liu; Xiao Qin; Lequn Li; Tangwei Liu; Zili Lu; Minyi Wei; Lunan Yan; Cheryl Ann Winkler; Stephen J. O'Brien; Jing Li; Kaiyin Xiao; and Tao Peng. 2017. "Preoperative transcatheter arterial chemotherapy may suppress oxidative stress in hepatocellular carcinoma cells and reduce the risk of short-term relapse." Oncotarget 8, (33): 54402-54415. doi:10.18632/oncotarget.17660.
DOI
10.18632/oncotarget.17660
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