Biology Faculty Articles
Document Type
Article
Publication Date
3-27-2021
Publication Title
Advanced Journal of Graduate Research
Keywords
14-3-3 protein, YWHA, 14-3-3 isoforms, binding partners, mammals
ISSN
2456-7108
Volume
10
Issue/No.
1
First Page
16
Last Page
22
Abstract
The 14-3-3 (YWHA or Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation proteins) are a family of abundant, highly conserved, ubiquitous, acidic, and homologous proteins expressed in most eukaryotes ranging from plants to animals, including humans, important in regulating a multitude of cellular processes such as signal transduction, cell cycle, protein trafficking, metabolism, apoptosis, and development. Mammals have been noted contain seven isoforms of these proteins (beta, epsilon, eta, gamma, sigma, tau/theta, and zeta), encoded by separate genes. The 14-3-3 proteins are known to interact with over 200 binding partners in isoform-specific, tissue-specific, and developmental stage-specific ways. The present review article encapsulates previously published research articles that report 14-3-3-interactors, and investigates isoform-specific interactions within a wide array of mammalian species, cells, tissues, organs, and developmental stages. Of the hundreds of binding partners of 14-3-3 discovered till date, this paper focuses on analyzing selected, representative interactors with key functional roles. The study would help a better understanding of isoform-specific interactions of this critical protein family in mammals
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
NSUWorks Citation
Covington, Taylor R. and Santanu De. 2021. "Binding Partners of 14-3-3 (YWHA) Protein Isoforms among Mammalian Species, Tissues, and Developmental Stages." Advanced Journal of Graduate Research 10, (1): 16-22. doi:10.21467/ajgr.10.1.16-22.
ORCID ID
0000-0002-0983-7996 , 0000-0002-9739-4039
DOI
10.21467/ajgr.10.1.16-22
Comments
Author(s) retains full copyright of their article and grants non-exclusive publishing right to this journal and its publisher “AIJR (India)”. Author(s) can archive pre-print, post-print and published version/PDF to any open access, institutional repository, social media or personal website provided that Published source must be acknowledged with citation and link to publisher version.