Publication Date
2024
Keywords
genomics, sharks, healing
Abstract
This research investigates differences in wound healing between sharks and humans, focusing on key components in the healing pathway. Sharks are known for their remarkable lesion-healing capabilities. Genes such as SERPIND1 play crucial roles in tissue remodeling for sharks while playing a role in cancer metastasis and inflammation in humans. The SERPIND1 gene codes for plasminogen activator inhibitor 1 (PAI-1), which is involved in blood clotting. This clotting process is vital for repairing dermal wounds, sealing off the damaged area, and preventing further blood loss. Comparative genomic analysis reveals distinctions between human and shark SERPIND1 genes at different levels such as nucleotide, amino acids, and chromosomal levels. The use of programs like StringDB and Ensembl helped us investigate protein interactions with each variant of SERPIND1. This led us to a broader understanding of the transformative changes between these variants through an evolutionary perspective. We discovered that both the human and shark homologs exhibit partial synteny, as several proteins, including PI4Kaa and Snap29, are present in both species. We discovered one extra splice site in the human SERPIND1 gene. Moreover, the human SERPIND1 had 8 exons compared to 7 exons in the shark homolog. Understanding these genetic factors and their roles in blood clotting enhances our knowledge of shark physiology and provides valuable insights that may inform advancements in human wound-healing strategies, opening avenues for further research and potential applications in medical science
Recommended Citation
Korivi, Vallabh; Angel, Samuel Samir; and Gill, Navdeep, "A Comparative Analysis of SERPIND1 in a Genomic Lens in Sharks" (2024). Bioinformatics. 5.
https://nsuworks.nova.edu/bioinformatics/5
COinS
This Research has been presented
Presented at Undergraduate Student Symposium USS held at NSU April 3-4, 2024