Document Type

Article

Publication Date

2008

Publication Title

Marine Drugs

Keywords

Okadaic acid, Polyketide, Polyketide synthase, Biosynthesis, Roseobacter

ISSN

1660-3397

Volume

6

Issue/No.

2

First Page

164

Last Page

179

Abstract

Okadaic acid (OA) and the related dinophysistoxins are isolated from dinoflagellates of the genus Prorocentrum and Dinophysis. Bacteria of the Roseobacter group have been associated with okadaic acid producing dinoflagellates and have been previously implicated in OA production. Analysis of 16S rRNA libraries reveals that Roseobacter are the most abundant bacteria associated with OA producing dinoflagellates of the genus Prorocentrum and are not found in association with non-toxic dinoflagellates. While some polyketide synthase (PKS) genes form a highly supported Prorocentrum clade, most appear to be bacterial, but unrelated to Roseobacter or Alpha-Proteobacterial PKSs or those derived from other Alveolates Karenia brevis or Crytosporidium parvum.

Comments

©2008 by the author(s); licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

Additional Comments

National Institute of Environmental Health Sciences grant #s: S11 ES11181, P50 ES12736-01; NSF grant #: 0432368; USDA grant #: NRICGP 2002-35201-11671

ORCID ID

0000-0002-1637-4125

ResearcherID

F-8809-2011

DOI

10.3390/md20080009