Marine & Environmental Sciences Faculty Articles
Platelet Satellitism and Dual Surface Immunoglobulin Light-Chain Expression in Circulating Splenic Marginal Zone Lymphoma Cells
Document Type
Article
Publication Date
2-1-2013
Publication Title
Annals of Diagnostic Pathology
Keywords
Satellitism, Flow cytometry, Lymphoma, Dual light chain expression, Transmission electron microscopy (TEM), Scanning electron microscopy (SEM)
ISSN
1092-9134
Volume
17
Issue/No.
1
First Page
117
Last Page
122
Abstract
Platelet satellitism is believed to be an in vitro phenomenon induced at room temperature in ethylenediamine tetraacetic acid–anticoagulated blood. Most reports involve neutrophils; involvement with circulating lymphoma cells are exceedingly rare. Normally, mature B cells exhibit allelic exclusion in which a single class of surface immunoglobulin light chains (either κ or λ ) is expressed. The simultaneous expression of both κ and λ immunoglobulin light chains is rare. Herein, we report the unusual case of a patient with splenic marginal zone lymphoma in which circulating lymphoma cells express dual surface immunoglobulin light chains and exhibit platelet satellitism. In addition to clinical findings, a comprehensive analysis of the peripheral blood including correlated light and electron microscopy as well as flow cytometry are described.
NSUWorks Citation
Naomi Montague, Patricia Blackwelder, Husain Ala Al Sayegh, Roberto Ochoa, Ximena Vial, and Gerald E. Byrne. 2013. Platelet Satellitism and Dual Surface Immunoglobulin Light-Chain Expression in Circulating Splenic Marginal Zone Lymphoma Cells .Annals of Diagnostic Pathology , (1) : 117 -122. https://nsuworks.nova.edu/occ_facarticles/443.
DOI
10.1016/j.anndiagpath.2011.06.001
Comments
©2013 Elsevier Inc.