Faculty Articles
Title
A mucoadhesive mouth wash, reduces the signs and symptoms of oral mucositis in patients with lichen planus: a double-blind randomized-control pilot study
ISBN or ISSN
2212-4403
Publication Title
Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology
Issue
6
Publication Date / Copyright Date
12-1-2014
First Page
657
Last Page
664
Publisher
Elsevier
DOI Number
10.1016/j.oooo.2014.07.007
Abstract
Objective
To determine if MuGard, a mouthwash shown to reduce the severity of oral mucositis when started before initiating antineoplastic therapy for head and neck cancers, is effective when painful, oral lesions are present in patients with biopsy-proven erosive oral lichen planus.
Study Design
This was a double-blind, randomized, placebo-controlled pilot study at a college of dental medicine. Twenty patients with oral lichen planus were randomly assigned to receive either MuGard (n = 10) or saline-bicarbonate control (n = 10). One teaspoonful of the assigned mouthwash was swished for 1 minute, 5 times a day, for 14 days. Outcome measures (Oral Mucositis Assessment Scale scores and visual analog scale pain scores) were obtained before the start of treatment and repeated on days 2, 7, and 14.
Results
Significant reductions in all outcome measures occurred in the MuGard-treated group. Number-needed-to-treat (NNT) to achieve a >50% reduction in averaged pain from baseline was 1.25, and to obtain complete relief, the NNT was 2.5.
Conclusions
MuGard significantly reduces pain and ulceration associated with oral mucositis in patients with lichen planus.
Disciplines
Dentistry
NSUWorks Citation
Velez, Inez; Spielholz, Neil I.; Siegel, Michael Alan; and Gonzalez, Tulia, "A mucoadhesive mouth wash, reduces the signs and symptoms of oral mucositis in patients with lichen planus: a double-blind randomized-control pilot study" (2014). Faculty Articles. 111.
https://nsuworks.nova.edu/hpd_cdm_facarticles/111
