College of Psychology: Faculty Articles

Title

Aging, Regional Cerebral Blood Flow, and Neuropsychological Functioning.

Document Type

Article

Publication Date

10-1984

Keywords

Aged, Aging, Cerebrovascular Circulation, Cognition, Luria-Nebraska Neuropsychological Battery, Middle Aged, Neuropsychological Tests, Regional Blood Flow, Xenon Radioisotopes.Journal of the American Geriatrics Society

Publication Title

Journal of the American Geriatrics Society

ISSN

0002-8614

Volume

32

Issue/No.

10

Peer Reviewed

1

Abstract

Previous studies found changes in regional cerebral blood flow (rCBF) patterns related to both age and various cognitive tasks. However, no study has yet demonstrated a relationship between rCBF and performance on the Luria-Nebraska Neuropsychological Battery (LNNB) in an elderly group. Seventy-nine elderly volunteers (56-88 years old), both healthy and demented, underwent the 133xenon inhalation rCBF procedure and were given the LNNB. The decrements in the gray-matter blood flow paralleled decrements in performance on the LNNB. Using partial correlations, a significant proportion of shared variance was observed between gray-matter blood flow and the LNNB scales. However, there was much less of a relationship between white-matter blood flow and performance on the LNNB. This study suggests that even within a restricted age sample rCBF is related in a global way to neuropsychological functioning.

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