Aging, Regional Cerebral Blood Flow, and Neuropsychological Functioning.

Author(s)

William D. MacInnes
Charles J. Golden, Nova Southeastern UniversityFollow
Robert W. Gillen
Robert F. Sawicki
M. Quaife
H. S. Uhl
A. H. Greenhouse

Document Type

Article

Publication Title

Journal of the American Geriatrics Society

ISSN

0002-8614

Publication Date

10-1984

Abstract

Previous studies found changes in regional cerebral blood flow (rCBF) patterns related to both age and various cognitive tasks. However, no study has yet demonstrated a relationship between rCBF and performance on the Luria-Nebraska Neuropsychological Battery (LNNB) in an elderly group. Seventy-nine elderly volunteers (56-88 years old), both healthy and demented, underwent the 133xenon inhalation rCBF procedure and were given the LNNB. The decrements in the gray-matter blood flow paralleled decrements in performance on the LNNB. Using partial correlations, a significant proportion of shared variance was observed between gray-matter blood flow and the LNNB scales. However, there was much less of a relationship between white-matter blood flow and performance on the LNNB. This study suggests that even within a restricted age sample rCBF is related in a global way to neuropsychological functioning.

Volume

32

Issue

10

First Page

712

Last Page

718

NSUWorks Citation

MacInnes, W. D., Golden, C. J., Gillen, R. W., Sawicki, R. F., Quaife, M., Uhl, H. S., Greenhouse, A. H. (1984). Aging, Regional Cerebral Blood Flow, and Neuropsychological Functioning.. Journal of the American Geriatrics Society, 32(10), 712-718.
Available at: https://nsuworks.nova.edu/cps_facarticles/650