Hormones, Menstrual Distress, and Migraine Across the Phases of the Menstrual Cycle

Author(s)

Jeffery L. Kibler, Nova Southeastern UniversityFollow
Jamie L. Rhudy
Donald B. Penzien
Jeanetta C. Rains
Rodney G. Meeks
William Bennett
Katherine M. Dollar, Jackson State UniversityFollow

Document Type

Article

Publication Title

Headache

ISSN

0017-8748

Publication Date

10-1-2005

Abstract

Objective—The primary objectives of the present study were to (1) contrast reproductive hormone levels and ratings of menstrual distress of female migraineurs with those of a control group in each menstrual cycle phase, (2) examine correlations between hormone levels and migraine frequency, severity, and migraine-related disability, and (3) examine correlations between menstrual distress and migraine frequency, severity, and migraine-related disability. A secondary objective was to evaluate the validity of a migraine disability measure modified to reflect 7-day recall.

Background—Further controlled, prospective study is needed regarding the temporal relationships between reproductive hormones at each stage of the menstrual cycle and fluctuations in migraine activity across the cycle.

Methods—Twenty-three women (17 with migraine, 6 control participants) completed laboratory hormone assays and measures of menstrual distress and disability at each phase of one menstrual cycle, and monitored their headache activity daily during the same cycle.

Results—The migraine group evidenced lower premenstrual luteinizing hormone and more menstrual distress symptoms at each phase of the menstrual cycle. Hormones were associated with migraine activity and disability within cycle phases, and across phases in a time-lagged manner. Menstrual distress was associated with ovulatory phase migraine activity and with migraine-related disability across the menstrual cycle. A retrospective 7-day migraine disability measure appeared to be a consistently valid index.

Conclusions—Both reproductive hormones and menstrually related distress appear to predict migraine activity and disability. These associations were evident not only for perimenstrual migraine, but also for migraine at each phase of the menstrual cycle.

DOI

10.1111/j.1526-4610.2005.00241.x

Volume

45

Issue

9

First Page

1181

Last Page

1189

NSUWorks Citation

Kibler, J. L., Rhudy, J. L., Penzien, D. B., Rains, J. C., Meeks, R. G., Bennett, W., Dollar, K. M. (2005). Hormones, Menstrual Distress, and Migraine Across the Phases of the Menstrual Cycle. Headache, 45(9), 1181-1189.
Available at: https://nsuworks.nova.edu/cps_facarticles/620