Faculty Articles
Cognitive Profiles In Alzheimer’s Disease and In Mild Cognitive Impairment Of Different Etiologies
Document Type
Article
Publication Title
Dementia and Geriatric Cognitive Disorders
ISSN
1420-8008
Publication Date
5-2006
Abstract
There has been increasing interest in determining whether amnestic, nonamnestic and multiple-domain subtypes of mild cognitive impairment (MCI) reflect different disease etiologies. In this study, we examined the extent to which cognitive profiles of nondemented patients with MCI diagnosed with prodromal Alzheimer's disease (AD) differed from those MCI patients diagnosed with vascular disease. We also compared these diagnostic groups to mildly demented patients diagnosed with AD and normal elderly controls. Results indicate that a majority of both MCI-AD and MCI-vascular patients experienced amnestic features and that multiple-domain was the most common presentation. MCI-AD and MCI-vascular groups did not differ on neuropsychological measures tapping memory, language, visuospatial skills/praxis or executive function. Further both MCI groups could be distinguished from dementia patients with regards to performance on measures of memory but not on non-memory measures. Considerable variability was observed in the degree of memory impairment among MCI patients with scores as much as 6 standard deviations below expected mean values. MCI-AD and MCI-vascular patients frequently exhibit both common and overlapping amnestic and nonamnestic features. The implication of these findings for future clinical research is discussed.
DOI
10.1159/000091522
Volume
21
Issue
5-6
First Page
309
Last Page
315
NSUWorks Citation
Loewenstein, D. A.,
Acevedo, A.,
Agron, J.,
Issacson, R.,
Strauman, S.,
Crocco, E.,
Barker, W.,
Duara, R.
(2006). Cognitive Profiles In Alzheimer’s Disease and In Mild Cognitive Impairment Of Different Etiologies. Dementia and Geriatric Cognitive Disorders, 21(5-6), 309-315.
Available at: https://nsuworks.nova.edu/cps_facarticles/235
