The compound genotype KIR3DS1/HLA-B Bw4-80I, which presumably favors natural killer cell activation, has been implicated in protection against HIV disease. We show that this genotype confers dual protection over the course of HIV disease; early direct containment of HIV viral load, and late specific defense against opportunistic infections, but not AIDS-related malignancies. The double protection of KIR3DS1/Bw4-80I in an etiologically complex disease such as AIDS, along with the disease specificity of its effects is conceptually novel and underscores the intricacy of host immunogenetics against HIV/AIDS.
Qi, Ying; Maureen P. Martin; Xiaojiang Gao; Lisa Jacobson; James J. Goedert; Susan Buchbinder; Gregory D. Kirk; Stephen J. O'Brien; John Trowsdale; and Mary Carrington. 2006. "KIR/HLA Pleiotropism: Protection against Both HIV and Opportunistic Infections." PLoS ONE 2, (8 e79): 741-745. http://nsuworks.nova.edu/cnso_bio_facarticles/784