Biology Faculty Articles

Document Type

Article

Publication Date

8-18-2006

Publication Title

PLoS ONE

ISSN

1932-6203

Volume

2

Issue/No.

8 e79

First Page

741

Last Page

745

Abstract

The compound genotype KIR3DS1/HLA-B Bw4-80I, which presumably favors natural killer cell activation, has been implicated in protection against HIV disease. We show that this genotype confers dual protection over the course of HIV disease; early direct containment of HIV viral load, and late specific defense against opportunistic infections, but not AIDS-related malignancies. The double protection of KIR3DS1/Bw4-80I in an etiologically complex disease such as AIDS, along with the disease specificity of its effects is conceptually novel and underscores the intricacy of host immunogenetics against HIV/AIDS.

Comments

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

Additional Comments

National Cancer Institute contract #: NO1-CO-12400

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015