Biology Faculty Articles

Title

AIDS Restriction HLA Allotypes Target Distinct Intervals of HIV-1 Pathogenesis

Document Type

Article

Publication Date

12-2005

Publication Title

Nature Medicine

ISSN

1078-8956

Volume

11

Issue/No.

12

First Page

1290

Last Page

1292

Abstract

An effective acquired immune response to infectious agents mediated by HLA-restricted T-cell recognition can target different stages of disease pathogenesis. We show here that three distinct HLA alleles known to alter the overall rate of AIDS progression act during distinct intervals after HIV-1 infection. The discrete timing of HLA allele influence suggests alternative functional mechanisms in immune defense against this dynamic and chronic immunosuppressive disease.

Comments

©2005 Nature Publishing Group

Additional Comments

National Cancer Institute contract #: NO1-CO-12400; National Institute on Drug Abuse grant #: DA04334

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015

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