Biology Faculty Articles

Title

Feline Immunodeficiency Virus (FIV) in Wild Pallas' Cats

Document Type

Article

Publication Date

3-15-2010

Publication Title

Veterinary Immunology and Immunopathology

Keywords

FIV, Pallas’ cat, Evolution, Histopathology, Felidae

ISSN

0165-2427

Volume

134

Issue/No.

1-2

First Page

90

Last Page

95

Abstract

Feline immunodeficiency virus (FIV), a feline lentivirus related to HIV, causes immune dysfunction in domestic and wild cats. The Pallas’ cat is the only species from Asia known to harbor a species-specific strain of FIV designated FIVOma in natural populations. Here, a 25% seroprevalence of FIV is reported from 28 wild Mongolian Pallas’ cats sampled from 2000 to 2008. Phylogenetic analysis of proviral RT-Pol from eight FIVOma isolates from Mongolia, Russia, China and Kazakhstan reveals a unique monophyletic lineage of the virus within the Pallas’ cat population, most closely related to the African cheetah and leopard FIV strains. Histopathological examination of lymph node and spleen from infected and uninfected Pallas’ cats suggests that FIVOma causes immune depletion in its’ native host.

Comments

©2009 Elsevier B.V. All rights reserved.

Additional Comments

National Cancer Institute contract #: N01-CO-12400; GenBank accession #s: GQ370820-GQ370824

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015

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