Effect of Host Genetics on the Development of Cytomegalovirus Retinitis in Patients with AIDS
Journal of Infectious Diseases
Background. Cytomegalovirus (CMV) retinitis is a common opportunistic infection among patients with AIDS and still causes visual morbidity despite the wide spread usage of highly active antiretroviral therapy (HAART). The ubiquitous CMV pathogen contains a human interleukin-10 (IL-10) homolog in its genome and utilizes it to evade host immune reactions through an IL-10 receptor mediated immune-suppression pathway.
Methods. Effects of IL-10R1, IL-10 and previously described AIDS restriction gene variants are investigated on the development of CMV retinitis in the Longitudinal Study of the Ocular Complications of AIDS (LSOCA) cohort (N = 1284).
Results. In European Americans (n = 750), a haplotype carrying an amino acid changing variation in the cytoplasmic domain (S420L) of IL-10R1 can be protective (OR, 0.14; 95% CI, 0.02–0.94; P = .04) against, whereas another haplotype carrying an amino acid changing variation in the extracellular domain (I224V) of IL-10R1 can be more susceptible (OR, 6.21; 95% CI, 1.22–31.54; P = .03) to CMV retinitis. In African Americans (n = 534), potential effects of IL-10 variants are observed.
Conclusion. Host genetics may have a role in the occurrence of CMV retinitis in patients infected with HIV.
Sezgin, Efe; Douglas A. Jabs; Sher L. Hendrickson; Mark Van Natta; Alexander Zdanov; Richard A. Lewis; Michael W. Smith; Jennifer L. Troyer; Stephen J. O'Brien; and SOCA Research Group. 2010. "Effect of Host Genetics on the Development of Cytomegalovirus Retinitis in Patients with AIDS." Journal of Infectious Diseases 202, (4): 606-613. http://nsuworks.nova.edu/cnso_bio_facarticles/441