Biology Faculty Articles

Title

Effect of Host Genetics on the Development of Cytomegalovirus Retinitis in Patients with AIDS

Document Type

Article

Publication Date

8-15-2010

Publication Title

Journal of Infectious Diseases

ISSN

0022-1899

Volume

202

Issue/No.

4

First Page

606

Last Page

613

Abstract

Background. Cytomegalovirus (CMV) retinitis is a common opportunistic infection among patients with AIDS and still causes visual morbidity despite the wide spread usage of highly active antiretroviral therapy (HAART). The ubiquitous CMV pathogen contains a human interleukin-10 (IL-10) homolog in its genome and utilizes it to evade host immune reactions through an IL-10 receptor mediated immune-suppression pathway.

Methods. Effects of IL-10R1, IL-10 and previously described AIDS restriction gene variants are investigated on the development of CMV retinitis in the Longitudinal Study of the Ocular Complications of AIDS (LSOCA) cohort (N = 1284).

Results. In European Americans (n = 750), a haplotype carrying an amino acid changing variation in the cytoplasmic domain (S420L) of IL-10R1 can be protective (OR, 0.14; 95% CI, 0.02–0.94; P = .04) against, whereas another haplotype carrying an amino acid changing variation in the extracellular domain (I224V) of IL-10R1 can be more susceptible (OR, 6.21; 95% CI, 1.22–31.54; P = .03) to CMV retinitis. In African Americans (n = 534), potential effects of IL-10 variants are observed.

Conclusion. Host genetics may have a role in the occurrence of CMV retinitis in patients infected with HIV.

Comments

© 2010 by the Infectious Diseases Society of America

Additional Comments

National Cancer Institute contract #: HHSN261200800001E; National Eye Institute grant #s: U10-EY-08052, U10-EY-08057, U10-EY-08067

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015

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