Abstract
The gut microbiome, a complex ecosystem of microorganisms residing in the human gastrointestinal tract, plays a crucial role in maintaining overall health. It functions in immune system regulation, digestion, and protection against pathogens. Apicomplexan parasites, such as Toxoplasma gondii, Plasmodium spp., and Cryptosporidium spp., are major pathogens that can significantly disrupt the gut microbiota, leading to alterations in microbial composition and function. This review explores the bidirectional interactions between Apicomplexan parasites and the gut microbiome, focusing on how these parasites influence microbial diversity, immune responses, and host metabolism. It examines the mechanisms by which infection-induced inflammation, altered nutrient absorption, and direct physical changes in the gut contribute to dysbiosis. Furthermore, it discusses how the composition of the microbiome can impact the survival and pathogenicity of Apicomplexan parasites, offering insights into potential microbiome-targeted treatments. By understanding the interactions between parasites and the gut microbiome, this review aims to support the development of future therapeutic approaches for managing parasitic infections and improving host recovery outcomes.
Recommended Citation
Bu, Senia and Ozga, Andrew T.
(2025)
"Host, Microbiome, and Parasite: How Apicomplexan Microorganisms Interact with Gut Microbiota,"
Mako: NSU Undergraduate Student Journal: Vol. 2025, Article 2.
Available at:
https://nsuworks.nova.edu/mako/vol2025/iss2/2
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Bacteria Commons, Microbial Physiology Commons, Parasitic Diseases Commons, Parasitology Commons