The purpose of this paper is to summarize the history of clover leaf syndrome and describe the newest advancements made to treat it. Clover leaf syndrome is more formally referred to as Kleeblattschadel syndrome. Information was gathered from several scholarly, peer-reviewed articles, and was condensed down into the key takeaways. This syndrome impacts the formation of the skull due to premature fusion of its sutures, creating a tri-lobar skull that resembles a clover leaf. This premature fusion is referred to as a type of craniosynostosis and has been linked to causing several other health complications ranging in severity. This is because the sutures of the skull are not supposed to permanently fuse until the second year of life, and early fusion negatively impacts development in the cranial region. With a documented mortality rate of 7%, new advancements have been made to combat the effects of this syndrome to improve the affected patient’s quality of life. While different strategies have been enacted, researchers have found a method that has been shown to have significant improvement in their condition, with better outcomes.



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