Presentation Title

Characterization of the Tissue Dielectric Constant of Skin Basal Cell Carcinoma

Speaker Credentials

Professor

Speaker Credentials

Ph.D.

College

College of Medical Sciences, MBS

Location

Nova Southeastern University, Davie, Florida, USA

Format

Poster

Start Date

16-2-2018 12:15 PM

End Date

16-2-2018 1:15 PM

Abstract

Objective: To characterize the tissue dielectric constant (TDC) of basal cell carcinoma (BCC). Background: In vitro dielectric constant measures of cancerous-tumors have shown differences compared to non-cancerous tumors. But, TDC values of BCC in vivo has not been characterized. Methods: In 30 patients, TDC of skin lesions to be biopsied was measured prior to biopsy at 300 MHz via the open ended coaxial line method to a depth of 0.5 mm. Lesion measurements were compared to values on non-affected skin. Patient age (mean ± SD) was 71.9±15.5 (35-95 years) with 19 males and 11 females included. Results: Biopsy results showed BCC for all 30 lesions of which 2/3 were classified as nodular and 1/5 as infiltrative. TDC values measured on lesions were overall significantly less than measured on contralateral non-affected skin (22.1±15.7 vs. 37.4±14.3, p < 0.0001). However, in four cases TDC values were greater on the lesions. These tended to be lesions that were either ulcerated or edematous. However, initial preliminary comparisons of measurements on non-cancerous lesions (n=10) indicate that average percentage differences between lesions and control skin are about 40% for both cancerous and non-cancerous lesions. Conclusions: Although significant differences in TDC values are found between BCC skin lesions and non-affected skin, the fact that there is so far, no clear separation between cancerous and non-cancerous differences, cautions that TDC measurements may have inadequate selectivity as a useful detection method. An increase in the number of non-cancerous lesion comparison measurements may provide further insight into this issue.

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Feb 16th, 12:15 PM Feb 16th, 1:15 PM

Characterization of the Tissue Dielectric Constant of Skin Basal Cell Carcinoma

Nova Southeastern University, Davie, Florida, USA

Objective: To characterize the tissue dielectric constant (TDC) of basal cell carcinoma (BCC). Background: In vitro dielectric constant measures of cancerous-tumors have shown differences compared to non-cancerous tumors. But, TDC values of BCC in vivo has not been characterized. Methods: In 30 patients, TDC of skin lesions to be biopsied was measured prior to biopsy at 300 MHz via the open ended coaxial line method to a depth of 0.5 mm. Lesion measurements were compared to values on non-affected skin. Patient age (mean ± SD) was 71.9±15.5 (35-95 years) with 19 males and 11 females included. Results: Biopsy results showed BCC for all 30 lesions of which 2/3 were classified as nodular and 1/5 as infiltrative. TDC values measured on lesions were overall significantly less than measured on contralateral non-affected skin (22.1±15.7 vs. 37.4±14.3, p < 0.0001). However, in four cases TDC values were greater on the lesions. These tended to be lesions that were either ulcerated or edematous. However, initial preliminary comparisons of measurements on non-cancerous lesions (n=10) indicate that average percentage differences between lesions and control skin are about 40% for both cancerous and non-cancerous lesions. Conclusions: Although significant differences in TDC values are found between BCC skin lesions and non-affected skin, the fact that there is so far, no clear separation between cancerous and non-cancerous differences, cautions that TDC measurements may have inadequate selectivity as a useful detection method. An increase in the number of non-cancerous lesion comparison measurements may provide further insight into this issue.