Student Theses, Dissertations and Capstones

Document Type


Degree Name

Master of Science (M.S.) in Clinical Vision Research

Copyright Statement

All rights reserved. This publication is intended for use solely by faculty, students, and staff of Nova Southeastern University. No part of this publication may be reproduced, distributed, or transmitted in any form or by any means, now known or later developed, including but not limited to photocopying, recording, or other electronic or mechanical methods, without the prior written permission of the author or the publisher.


College of Optometry

First Advisor

Bin Zhang

Second Advisor

Hua Bi

Third Advisor

Xiaojing Yu

Publication Date / Copyright Date



Nova Southeastern University


Purpose: The purpose of this study is to evaluate the treatment and management of anisometropia with orthokeratology lenses compared to traditional spectacle lenses. The present study aimed to quantify the interocular difference in relative corneal refractive power shift and examine its association with the differential axial growth.

Methods: One hundred and two subjects between the ages 8 and 14 years old with over -0.50D of myopia and at least 1D of anisometropia were treated with either orthokeratology lenses or traditional single vision spectacle lenses. Baseline data of axial length, refraction, and corneal topography were taken at the initial visit and again one year after treatment.

Results: Subjects treated with orthokeratology lenses, showed a significantly decreased the interocular difference in axial length one year after lens placement (p<0.001). In the control subjects who wore spectacles, the interocular difference in axial length did not change significantly (p = 0.64). In the orthokeratology group, the less myopic eyes had significantly larger ALG (0.15 ± 0.15 mm) than the more myopic eyes (0.06 ± 0.15 mm, p < 0.001). In the spectacle group, ALGs were similar in both eyes (0.26 ± 0.19 mm in the eyes with greater myopia vs. 0.28 ± 0.16 mm in the eyes with less myopia, p = 0.87). A significant correlation was also found between the interocular difference in the sum of RCRPS and interocular difference in axial length growth at one-year follow-up (r = –0.67, p < 0.001).

Conclusion: A clear relationship was observed between the interocular difference in RCRPS and interocular difference of axial length growth in the children withanisometropia treated with orthokeratology lenses.




Orthokeratology lenses, Interocular difference, Corneal refractive power shift, Differential axial growth, Pediatric vision



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