NSU-MD Faculty Articles

Title

Adenosine and coronary blood flow in conscious dogs during normal physiological stimuli.

ISBN or ISSN

0002-9513

Publication Title

The American journal of physiology

Volume

243

Issue

4

Publication Date / Copyright Date

10-1-1982

First Page

H628

Last Page

H633

Publisher

American Physiological Society

DOI Number

10.1152/ajpheart.1982.243.4.H628

Abstract

The role of adenosine in matching myocardial oxygen supply to demand by regulating coronary blood flow has been the subject of intensive study. The present experiments were designed to determine the relationship among myocardial oxygen consumption, coronary blood flow, and adenosine production as estimated by pericardial adenosine accumulation under several physiological conditions in the same animal. Conscious chronically instrumented dogs were used to measure changes in coronary blood flow, myocardial oxygen consumption, and pericardial adenosine accumulation during two levels of treadmill exercise, excitement caused by loud noises, and feeding (the presentation and consumption of a meal). The results show significant increases in the adenosine production with all experimental procedures and significant linear correlations between myocardial oxygen consumption and coronary blood flow (r = 0.78), myocardial oxygen consumption and adenosine production (r = 0.73), and adenosine production and coronary blood flow (r = 0.88). These data show that increases in adenosine production by the normally oxygenated myocardium can be the physiological mechanism for matching oxygen supply to increased oxygen demand in the conscious dog.

Disciplines

Medicine and Health Sciences

Keywords

Adenosine, Animals, Blood Pressure, Coronary Vessels, Dogs, Heart Rate, Kinetics, Myocardium, Oxygen Consumption, Regional Blood Flow, Vascular Resistance

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