corticosteroid, in vitro fertilization (ivf), oophoritis, anti-ovarian antibody, covid-19
Anti-ovarian antibodies (AOAs) have been linked to autoimmune premature ovarian insufficiency (POI). This report details a case in which a patient experienced transient POI after a COVID-19 infection and tested positive for AOA. After treatment with oral contraceptives and subsequent high-dose oral corticosteroids, the patient underwent fertility treatment with in vitro fertilization (IVF). A total of 23 oocytes were retrieved. Two euploid blastocysts and three untested blastocysts were successfully created. This report hypothesizes the connection between autoimmune POI, AOA, and COVID-19. Conflicting data have been reported linking COVID-19 and ovarian injury. However, it is suggested that COVID-19 transiently impacts the menstrual cycle and anti-Mullerian hormone (AMH) levels. Treatment to overcome poor ovarian response due to AOA has not been adequately determined; however, similar autoimmune conditions have been successfully treated with corticosteroids.
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Gorman, Colleen N.; Abdalla, Tori E.; Sultan, Yasmina; Grabois, Spencer A.; and Wood, Ellen G., "Transient Premature Ovarian Insufficiency Post-COVID-19 Infection." (2023). HPD Articles. 385.
© Copyright 2023 Gorman et al.