Simvastatin and Oncolytic Vesicular Stomatitis Virus Actions on HeLa Cells

Authors

Paula A. Faria-Waziry, Nova Southeastern UniversityFollow
Francisco Puerta, Nova Southeastern University
Giulio Rottaro
Ana M. Castejon, Nova Southeastern UniversityFollow
Luigi X. Cubeddu, Nova Southeastern University

Publication Title

Current Topics in Pharmacology

Volume

21

Publication Date / Copyright Date

2017

First Page

17

Last Page

25

Publisher

Research Trends (P) Ltd.

Abstract

Statins, the cholesterol-lowering drugs, are known to exert pleiotropic actions including anticancer and antiviral effects. The interaction between simvastatin and oncolytic vesicular stomatitis virus (VSV), a potential candidate for anticancer therapy, was investigated. HeLa cells in culture were exposed to simvastatin and/or VSV-green fluorescence protein (GFP) at different times and concentrations.

Disciplines

Medicine and Health Sciences | Pharmacy and Pharmaceutical Sciences

Keywords

antiviral, apoptosis, simvastatin, vesicular stomatitis virus

NSUWorks Citation

Faria-Waziry, Paula A.; Puerta, Francisco; Rottaro, Giulio; Castejon, Ana M.; and Cubeddu, Luigi X., "Simvastatin and Oncolytic Vesicular Stomatitis Virus Actions on HeLa Cells" (2017). Faculty Articles. 274.
https://nsuworks.nova.edu/hpd_corx_facarticles/274