C8-Guanine modifications: effect on Z-DNA formation and its role in cancer
ISBN or ISSN
Organic & Biomolecular Chemistry
Publication Date / Copyright Date
Royal Society of Chemistry
Base modifications are known to affect the structure and function of DNA. C8-guanine adducts from various carcinogenic compounds have been shown to be potent Z-DNA inducers. Hence, it has been hypothesized that Z-DNA plays a role in cancer and other genetic diseases. In this comprehensive review, Z-DNA and the effect of prevalent C8-guanine adducts on the B–Z transition are addressed. The discoveries of Z-DNA binding proteins including ADAR1, E3L, DLM1, and PKZ have suggested the relevance of Z-DNA in living systems. In addition, increasing evidence on the Z-DNA connection to gene transcription and inhibition reveals potential biological functions of the left-handed DNA. Finally, C8-guanine adducts that promote Z-DNA formation can be used as a tool to explore the Z-DNA function and its role in carcinogenesis.
Medicine and Health Sciences | Pharmacy and Pharmaceutical Sciences
Vongsutilers, V. and Gannett, Peter M., "C8-Guanine modifications: effect on Z-DNA formation and its role in cancer" (2018). Faculty Articles. 247.