Faculty Articles

Title

C8-Guanine modifications: effect on Z-DNA formation and its role in cancer

ISBN or ISSN

1477-0539

Publication Title

Organic & Biomolecular Chemistry

Issue

13

Publication Date / Copyright Date

2018

First Page

2198

Last Page

2209

Publisher

Royal Society of Chemistry

DOI Number

10.1039/C8OB00030A

Abstract

Base modifications are known to affect the structure and function of DNA. C8-guanine adducts from various carcinogenic compounds have been shown to be potent Z-DNA inducers. Hence, it has been hypothesized that Z-DNA plays a role in cancer and other genetic diseases. In this comprehensive review, Z-DNA and the effect of prevalent C8-guanine adducts on the B–Z transition are addressed. The discoveries of Z-DNA binding proteins including ADAR1, E3L, DLM1, and PKZ have suggested the relevance of Z-DNA in living systems. In addition, increasing evidence on the Z-DNA connection to gene transcription and inhibition reveals potential biological functions of the left-handed DNA. Finally, C8-guanine adducts that promote Z-DNA formation can be used as a tool to explore the Z-DNA function and its role in carcinogenesis.

Disciplines

Medicine and Health Sciences | Pharmacy and Pharmaceutical Sciences

Peer Reviewed

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