Faculty Articles
Title
Mouse alpha 1-protease inhibitor is not an acute phase reactant
ISBN or ISSN
0003-9861
Publication Title
Archives of biochemistry and biophysics
Volume
246
Issue
1
Publication Date / Copyright Date
4-1-1986
First Page
488
Last Page
493
Publisher
Academic Press
DOI Number
10.1016/0003-9861(86)90495-9
Abstract
Mouse plasma contains two major protease inhibitors, alpha 1-protease inhibitor (alpha 1-PI) and contrapsin, which have high affinity for bovine trypsin. Systemic injury, such as turpentine-induced inflammation, did not change the plasma concentration of alpha 1-PI, but increased that of contrapsin by 50%. The concentration of hepatic alpha 1-PI mRNA was determined by Northern blot hybridization and was not significantly affected by the acute phase reaction. J.M. Frazer, S.A. Nathoo, J. Katz, T.L. Genetta, and T.H. Finley [1985) Arch. Biochem. Biophys. 239, 112-119) have reported a threefold increase of mRNA for the elastase specific alpha 1-PI but this increase was not demonstrated by the present study. The mRNAs for known mouse acute phase plasma proteins were, however, stimulated severalfold by the same treatment. These results indicate that in the mouse, as opposed to human, alpha 1-PI is not an acute phase reactant.
Disciplines
Medicine and Health Sciences | Pharmacy and Pharmaceutical Sciences
Keywords
Acute-Phase Proteins, Animals, Blood Proteins, DNA, Immunoelectrophoresis, Two-Dimensional, Inflammation, Liver, Male, Mice, Mice, Inbred C57BL, RNA, Messenger, Serpins, Trypsin Inhibitors, alpha 1-Antitrypsin
NSUWorks Citation
Baumann, H; Latimer, Jean Johanna; and Glibetic, M D., "Mouse alpha 1-protease inhibitor is not an acute phase reactant" (1986). Faculty Articles. 20.
https://nsuworks.nova.edu/hpd_corx_facarticles/20
