Faculty Articles

Title

Cardiac βarrestin2 Improves Contractility and Adverse Remodeling in Heart Failure, But Is Underexpressed in Humans

ISBN or ISSN

1558-3597

Publication Title

Journal of the American College of Cardiology

Volume

70

Issue

23

Publication Date / Copyright Date

12-2017

First Page

2948

Last Page

2949

Publisher

Elsevier Inc.

DOI Number

10.1016/j.jacc.2017.10.008

Abstract

In summary, our present study aims to bring the attention of clinicians and pharmacologists to the remarkable functional divergence of the 2 βarrestins in the heart, which, coupled with the virtual absence of the “good” cardiac βarrestin2 protein in humans, highlights potential causes of 2 recent clinical failures of novel, otherwise promising therapies for human HF. Importantly, it points to a “missing link” (boosting endogenous cardiac βarrestin2 levels) for these therapeutics that is necessary to attain efficacy for human HF treatment.

Disciplines

Medicine and Health Sciences | Pharmacy and Pharmaceutical Sciences

Keywords

cardiac βarrestin2, heart failure, humans

Peer Reviewed

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