Faculty Articles

PubMed Identifier

22510004

Advances in ocular drug delivery

Publication Title

Current eye research

Volume

37

Issue

5

Publication Date / Copyright Date

5-1-2012

First Page

345

Last Page

356

DOI Number

10.3109/02713683.2011.652286

Abstract

Eye drops have long been the primary ocular drug delivery dosage form used to treat ocular disorders ranging from superficial conditions to intravitreal diseases. The ocular anatomical structure and physiological protective mechanisms are one of the most formidable barriers to drug penetration that have significantly reduced the drug's efficacy and target selectivity while sometimes causing ocular tissue damage. There are many new and innovative advances in ocular drug delivery due to better understanding of the structure and function of the eye, the nature of its diseases, and how to overcome or utilize its protective barrier(s), which resulted in increased bioavailability and longer duration of action of the administered drugs, therefore, more effective disease management. We seek in this article to present a comprehensive overview of the basic required knowledge about the barriers for drug delivery to the eye and the major breakthroughs and advances in ocular drug delivery to the anterior, posterior and intravitreal segments of the eye.

Disciplines

Medicine and Health Sciences | Pharmacy and Pharmaceutical Sciences

Keywords

Anterior Eye Segment, Conjunctiva, Drug Delivery Systems, Drug Implants, Emulsions, Eye Diseases, Humans, Intravitreal Injections, Iontophoresis, Ophthalmic Solutions, Posterior Eye Segment

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