Faculty Articles
Angiotensin II Type 2 Receptor-Expressing Neurons in the Central Amygdala Influence Fear-Related Behavior
ISBN or ISSN
0006-3223
Publication Title
Biological Psychiatry
Volume
86
Issue
12
Publication Date / Copyright Date
12-15-2019
First Page
899
Last Page
909
Publisher
Elsevier
DOI Number
10.1016/j.biopsych.2019.05.027
Abstract
BACKGROUND: The renin-angiotensin system has been implicated in posttraumatic stress disorder; however, the mechanisms responsible for this connection and the therapeutic potential of targeting the renin-angiotensin system in posttraumatic stress disorder remain unknown. Using an angiotensin receptor bacterial artificial chromosome (BAC) and enhanced green fluorescent protein (eGFP) reporter mouse, combined with neuroanatomical, pharmacological, and behavioral approaches, we examined the role of angiotensin II type 2 receptor (AT
METHODS: Dual immunohistochemistry with retrograde labeling was used to characterize AT
RESULTS: AT
CONCLUSIONS: These findings suggest that CeM AT
Disciplines
Medicine and Health Sciences | Pharmacy and Pharmaceutical Sciences
Keywords
AT(2)R; Amygdala; Angiotensin II; Mouse; PTSD; Pavlovian fear conditioning
Rights
(c) 2019 Society of Biological Psychiatry
NSUWorks Citation
Yu, Zhe; Swiercz, Adam P; Moshfegh, Cassandra M; Hopkins, Lauren; Wiaderkiewicz, Jan; Speth, Robert Charles; Park, Jeanie; and Marvar, Paul J, "Angiotensin II Type 2 Receptor-Expressing Neurons in the Central Amygdala Influence Fear-Related Behavior" (2019). Faculty Articles. 118.
https://nsuworks.nova.edu/hpd_corx_facarticles/118
Additional Comments
This research and PJM were supported by the National Institutes of Health (Grant No. NIH1R01HL137103-01A1 [to PJM]) and the American Heart Association (Grant No. 15CSA24340001 [to PJM]).