Faculty Articles

Title

Angiotensin II Type 2 Receptor-Expressing Neurons in the Central Amygdala Influence Fear-Related Behavior

Publication Title

Biological psychiatry

Volume

86

Issue

12

Publication Date / Copyright Date

12-15-2019

First Page

899

Last Page

909

Publisher

Elsevier

DOI Number

10.1016/j.biopsych.2019.05.027

Abstract

BACKGROUND: The renin-angiotensin system has been implicated in posttraumatic stress disorder; however, the mechanisms responsible for this connection and the therapeutic potential of targeting the renin-angiotensin system in posttraumatic stress disorder remain unknown. Using an angiotensin receptor bacterial artificial chromosome (BAC) and enhanced green fluorescent protein (eGFP) reporter mouse, combined with neuroanatomical, pharmacological, and behavioral approaches, we examined the role of angiotensin II type 2 receptor (AT

METHODS: Dual immunohistochemistry with retrograde labeling was used to characterize AT

RESULTS: AT

CONCLUSIONS: These findings suggest that CeM AT

Disciplines

Medicine and Health Sciences | Pharmacy and Pharmaceutical Sciences

Keywords

AT(2)R; Amygdala; Angiotensin II; Mouse; PTSD; Pavlovian fear conditioning

Peer Reviewed

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