Faculty Articles

PubMed Identifier

28791183

Title

Alterations in Gene Expression of Components of the Renin-Angiotensin System and Its Related Enzymes in Lung Cancer

Publication Title

Lung Cancer Int

Volume

2017

Publication Date / Copyright Date

1-1-2017

First Page

6914976

Last Page

6914976

Publisher

Hindawi

DOI Number

10.1155/2017/6914976

Abstract

OBJECTIVES: The study assessed the existence and significance of associations between the expression of fifteen renin-angiotensin system component genes and lung adenocarcinoma.

MATERIALS AND METHODS: NCBI's built-in statistical tool, GEO2R, was used to calculate Student's

RESULTS: Ten genes were found to be significantly associated with adenocarcinoma. Seven of these associations remained statistically significant after correction for multiple comparisons. Notably, AGTR2, which encodes the AT

CONCLUSION: The results suggest an association between the expression of the genes for renin-angiotensin system-related proteins and adenocarcinoma. While further research is necessary to conclusively demonstrate a link between the renin-angiotensin system and lung cancers, the results suggest that the renin-angiotensin system plays a role in the pathology of adenocarcinoma.

Disciplines

Medicine and Health Sciences | Pharmacy and Pharmaceutical Sciences

Peer Reviewed

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