Alterations in Gene Expression of Components of the Renin-Angiotensin System and Its Related Enzymes in Lung Cancer
Lung Cancer Int
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OBJECTIVES: The study assessed the existence and significance of associations between the expression of fifteen renin-angiotensin system component genes and lung adenocarcinoma.
MATERIALS AND METHODS: NCBI's built-in statistical tool, GEO2R, was used to calculate Student's
RESULTS: Ten genes were found to be significantly associated with adenocarcinoma. Seven of these associations remained statistically significant after correction for multiple comparisons. Notably, AGTR2, which encodes the AT
CONCLUSION: The results suggest an association between the expression of the genes for renin-angiotensin system-related proteins and adenocarcinoma. While further research is necessary to conclusively demonstrate a link between the renin-angiotensin system and lung cancers, the results suggest that the renin-angiotensin system plays a role in the pathology of adenocarcinoma.
Medicine and Health Sciences | Pharmacy and Pharmaceutical Sciences
Goldstein, Benjamin; Trivedi, Malav Suchin; and Speth, Robert Charles, "Alterations in Gene Expression of Components of the Renin-Angiotensin System and Its Related Enzymes in Lung Cancer" (2017). Faculty Articles. 111.