Student Theses, Dissertations and Capstones

Document Type

Thesis - NSU Access Only

Degree Name

Master of Science (M.S.) in Dentistry

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College of Dental Medicine

Publication Date / Copyright Date



Nova Southeastern University


"A thesis submitted to the College of Dental Medicine of Nova Southeastern University of the degree of Master of Science in Dentistry."

Objective: To compare the differences in new bone formation between Regenaform® (control) and a new material Healos® (test) when used with GBR (guided bone regeneration). Background: Subsequent to loss of teeth, supporting alveolar bone is predictably lost, comprising optimal dental implant placement. GBR is a procedure that augments deficient bone in preparation for a dental implant. Methods: Subjects in need of a dental implant but with insufficient bone were recruited to participate in the study. The control group received GBR with Regenaform® grafting material and the experimental group received GBR with Healos® grafting material. Implant placement into the GBR sites was performed six months after GBR surgery. Bone regeneration was assessed by comparison of pre- and post-operative cone-beam CT scans (CBCT) and dental stone models. At the time of implant placement, bone cores that would normally be discarded were obtained from four control group sites and four experimental sites and were analyzed histologically. Results: Comparison of CBCTs showed the horizontal bone augmentation obtained with GBR using Healos® graft material is much less compared to GBR using Regenaform® (1.57 mm versus 2.81 mm). All Healos® sites exhibited delayed short-term healing with excessive erythema, edema and suppuration. Histologic analysis shows that Healos® heals with similar vital bone and similar marrow and fibrous tissue compared to Regenaform®. Conclusion: The use of Healos® grafting material for use in GBR cannot be recommended when more predictable grafting materials such as Regenaform® are available.





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