Biology Faculty Books and Book Chapters

Chapter One - The mechanisms and cell signaling pathways of programmed cell death in the bacterial world

Chapter One - The mechanisms and cell signaling pathways of programmed cell death in the bacterial world

Book Title

International Review of Cell and Molecular Biology

Files

Document Type

Book Chapter

Editors

Johan K.E. Spetz, Lorenzo Galluzzi

Description

While programmed cell death was once thought to be exclusive to eukaryotic cells, there are now abundant examples of well regulated cell death mechanisms in bacteria. The mechanisms by which bacteria undergo programmed cell death are diverse, and range from the use of toxin-antitoxin systems, to prophage-driven cell lysis. Moreover, some bacteria have learned how to coopt programmed cell death systems in competing bacteria. Interestingly, many of the potential reasons as to why bacteria undergo programmed cell death may parallel those observed in eukaryotic cells, and may be altruistic in nature. These include protection against infection, recycling of nutrients, to ensure correct morphological development, and in response to stressors. In the following chapter, we discuss the molecular and signaling mechanisms by which bacteria undergo programmed cell death. We conclude by discussing the current open questions in this expanding field.

ISBN

978-0-12-819929-9

Publication Date

2021

Publisher

Elsevier

Keywords

Toxin-antitoxin system, Cell lysis, Altruism, Bacteriophage, Bacterial cooperation, Bacterial development, SOS response pathway, Abortive phage infection, Population heterogeneity, Cooperation

Disciplines

Cell and Developmental Biology | Life Sciences

ORCID ID

0000-0003-2744-7390

DOI

10.1016/bs.ircmb.2019.12.002

Chapter One - The mechanisms and cell signaling pathways of programmed cell death in the bacterial world
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