Chapter One - The mechanisms and cell signaling pathways of programmed cell death in the bacterial world
International Review of Cell and Molecular Biology
Johan K.E. Spetz, Lorenzo Galluzzi
While programmed cell death was once thought to be exclusive to eukaryotic cells, there are now abundant examples of well regulated cell death mechanisms in bacteria. The mechanisms by which bacteria undergo programmed cell death are diverse, and range from the use of toxin-antitoxin systems, to prophage-driven cell lysis. Moreover, some bacteria have learned how to coopt programmed cell death systems in competing bacteria. Interestingly, many of the potential reasons as to why bacteria undergo programmed cell death may parallel those observed in eukaryotic cells, and may be altruistic in nature. These include protection against infection, recycling of nutrients, to ensure correct morphological development, and in response to stressors. In the following chapter, we discuss the molecular and signaling mechanisms by which bacteria undergo programmed cell death. We conclude by discussing the current open questions in this expanding field.
Toxin-antitoxin system, Cell lysis, Altruism, Bacteriophage, Bacterial cooperation, Bacterial development, SOS response pathway, Abortive phage infection, Population heterogeneity, Cooperation
Cell and Developmental Biology | Life Sciences
Smith, Robert; Ivana Barraza; Rebecca J. Quinn; and Marla Fortoul. (2021). Chapter One - The mechanisms and cell signaling pathways of programmed cell death in the bacterial world. In Johan K.E. Spetz, Lorenzo Galluzzi (Eds.), International Review of Cell and Molecular Biology (1-53).