Title

Evolutionary Analysis of the 5'-Terminal Region of Hepatitis G Virus Isolated From Different Regions in China

Authors

Ping An, National Cancer Institute at Frederick; Lanzhou Medical College - People's Republic of China
Li Wei, Lanzhou Medical College - People's Republic of China
Xueyun Wu, National Cancer Institute at Frederick
Naoya Yuhki, National Cancer Institute at Frederick
Stephen J. O'Brien, National Cancer Institute at FrederickFollow
Cheryl Winkler, National Cancer Institute at Frederick

Document Type

Article

Publication Date

10-1997

Publication Title

Journal of Virology

ISSN

0022-1317

Volume

78

Issue/No.

10

First Page

2477

Last Page

2482

Abstract

We have determined the nucleotide sequence of the 5'-terminal region of the hepatitis G virus (HGV) genome in 11 hepatitis patients from three cities in China. Phylogenetic analyses revealed that the Chinese isolates were genetically distinct from previously described West African isolates (type 1) and American, European and East African isolates (type 2), with a mean sequence divergence of approximately 10%. The mean divergence between isolates from Lanzhou, in the northwest of China, and those from Shanghai and Nanjing, on the east coast of China, was 5% (range 3-7%). The isolates from Shanghai and Nanjing were closely related to a common strain in Japan, while some of those from Lanzhou were closely related to a southeast Asian type 3 isolate. Thus, the Chinese isolates belong to the type 3 variant of HGV.

Comments

©1997 US Government

Additional Comments

GenBank accession #s: U89148-U89158

NSUWorks Citation

An, Ping; Li Wei; Xueyun Wu; Naoya Yuhki; Stephen J. O'Brien; and Cheryl Winkler. 1997. "Evolutionary Analysis of the 5'-Terminal Region of Hepatitis G Virus Isolated From Different Regions in China." Journal of Virology 78, (10): 2477-2482. https://nsuworks.nova.edu/cnso_bio_facarticles/684

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015