Hepatitis C Virus Load is Associated with Human Immunodeficiency Virus Type 1 Disease Progression in Hemophiliacs
Journal of Infectious Diseases
acquired immunodeficiency syndrome, hepatitis c rna, cell count, disease progression, hiv-1, rna, hepatitis c virus
Hepatitis C virus (HCV) and human immunodeficiency virus type 1 (HIV-1) coinfection is common in hemophiliacs and injection drug users. To assess the interaction between HCV load and HIV-1 disease progression, we examined 207 HIV-1/HCV-coinfected patients. Patients were followed prospectively for ∼7 years, and annual measurements of CD4⁺ cell counts and HCV and HIV-1 loads were obtained. Survival analysis was used to define the independent effects of HCV load on HIV-1 progression. After controlling for CD4⁺ cell count and HIV1 RNA level, every 10-fold increase in baseline HCV RNA was associated with a relative risk (RR) for clinical progression to acquired immunodeficiency syndrome (AIDS) of 1.66 (95% confidence interval [CI], 1.10-2.51; P = .016) and an RR for AIDS-related mortality of 1.54 (95% CI, 1.03-2.30; P = .036). These findings emphasize the need for further research regarding the use of HIV-1- and HCV-specific therapy in coinfected individuals.
Daar, Eric S.; Henry Lynn; Sharyne Donfield; Edward Gomperts; Stephen J. O'Brien; Margaret Hilgartner; Keith Hoots; David Chernoff; Steven Arkin; W.-Y. Wong; Cheryl Winkler; and Hemophilia Growth and Development Study. 2001. "Hepatitis C Virus Load is Associated with Human Immunodeficiency Virus Type 1 Disease Progression in Hemophiliacs." Journal of Infectious Diseases 183, (4): 589-595. https://nsuworks.nova.edu/cnso_bio_facarticles/635